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  4. Ipamorelin Side Effects: What You Should Know

    Ipamorelin Side Effects: What You Should Know

    Ipamorelin is a synthetic peptide that has gained popularity
    among athletes, bodybuilders, and individuals seeking
    anti‑aging benefits. While it can stimulate growth hormone release effectively, it’s essential
    to understand the potential side effects and how to
    use it responsibly.

    What Is Ipamorelin?

    Ipamorelin is a small, selective growth hormone secretagogue that
    mimics ghrelin, the “hunger hormone.” Developed in the 1990s, it was originally intended for
    research purposes but has since become widely used in performance enhancement and clinical settings.

    The peptide binds to GHS‑R1a receptors on pituitary cells, prompting the release of growth hormone (GH) without significantly affecting prolactin or cortisol levels.

    How Ipamorelin Works

    When injected, ipamorelin stimulates the hypothalamic–pituitary axis.
    It signals the pituitary gland to secrete GH in pulses that
    mirror natural circadian rhythms. Because its action is highly selective,
    it offers a more favorable side‑effect profile compared to older secretagogues like GHRP‑6 or sermorelin.

    Common Side Effects of Ipamorelin

    Most users report only mild, transient reactions after dosing.
    These typically resolve within hours and are often dose dependent.

    Mild Side Effects

    Injection site irritation: Redness, swelling, or a slight ache where
    the peptide is injected.

    Headaches: Occur in some individuals, especially during the first few weeks of use.

    Water retention: Minor puffiness or bloating, usually noticeable in the face
    or extremities.

    Increased appetite: A natural response to ghrelin activity, which can lead to mild weight
    gain if not monitored.

    How to Manage These Side Effects

    Rotate injection sites to prevent irritation and scar tissue build‑up.

    Use a cold compress after injection to reduce swelling and pain.

    Stay hydrated; adequate water intake helps mitigate fluid retention.

    Monitor diet to control appetite spikes, focusing
    on balanced protein and low‑glycemic carbs.

    Serious Side Effects & Potential Risks

    While ipamorelin is generally safe, rare but significant adverse events can occur, particularly with improper
    dosing or preexisting health conditions.

    Less Common but Serious Side Effects

    Hormonal imbalances: Excessive GH may disrupt thyroid
    function or insulin sensitivity.

    Joint pain or arthralgia: Over‑stimulation of cartilage growth could stress joints
    over time.

    Sleep disturbances: Elevated GH levels can affect sleep architecture, leading to insomnia or fragmented rest.

    How to Reduce These Risks

    Adhere strictly to prescribed dosages. Over‑dosing increases the chance of hormonal disruption.

    Regular blood work to monitor hormone panels (GH, IGF‑1, thyroid, insulin).

    Use a sleep aid or routine if GH elevations disturb
    circadian rhythms.

    Consult with a healthcare professional before combining ipamorelin with other supplements that influence hormone levels.

    Long-Term Risks of Ipamorelin: What Does Science Say?

    Research on long‑term use is limited, but existing studies highlight potential concerns:

    Potential Long-Term Risks

    Oncogenic potential: Chronic high GH can theoretically promote
    tumor growth in susceptible tissues.

    Cardiovascular strain: Persistent GH elevation may increase
    blood pressure or affect lipid metabolism.

    Bone density changes: Although GH supports bone health, imbalances could lead to abnormal remodeling.

    How to Use Ipamorelin Safely

    Start with low doses and gradually titrate under medical supervision.

    Follow a cycle schedule (e.g., 12–16 weeks on, 4
    weeks off) to allow the body’s natural balance to reset.

    Maintain comprehensive health monitoring, including
    liver enzymes, kidney function, and metabolic panels.

    Avoid simultaneous use of other GH secretagogues unless directed by a
    clinician.

    How Evolve Medical Group Can Help

    Evolve Medical Group offers tailored protocols for ipamorelin therapy, emphasizing safety and efficacy:

    Personalized dosing plans based on individual hormone profiles.

    In‑clinic monitoring with blood tests to track changes in GH, IGF‑1, thyroid, and metabolic markers.

    Educational resources about injection techniques, side‑effect management, and lifestyle adjustments.

    Follow‑up consultations to adjust protocols or discontinue therapy if adverse effects emerge.

    Conclusion: Ipamorelin Side Effects

    Ipamorelin’s appeal lies in its targeted growth hormone stimulation with fewer systemic disruptions than older agents.
    Nevertheless, users must remain vigilant about mild side effects, monitor
    for serious risks, and seek professional guidance when integrating it into a health regimen. Responsible use—combined with regular medical oversight—can help maximize
    benefits while minimizing potential harm.

    FAQs: Ipamorelin Side Effects

    Q: Can ipamorelin side effects cancer cause acne?

    A: Rarely; most skin reactions are injection‑site related, not widespread acne.

    Q: Is it safe for women?

    A: Women can use ipamorelin, but they should be aware of potential menstrual
    cycle changes and consult a healthcare provider.

    Q: How soon after injection do side effects appear?

    A: Mild effects like headache or swelling typically manifest within an hour
    post‑dose.

    Q: Can I mix ipamorelin with other supplements?

    A: Only under professional guidance, especially if the other supplement affects
    hormone levels (e.g., testosterone boosters).

    Q: What should I do if I notice joint pain?

    A: Reduce dosage or pause therapy and discuss symptoms with a clinician.

  5. Anavar Cycle Guide: Safe Dosage & Best Results 2025

    Sign up for Newsletter

    Stay updated on the latest trends in performance enhancement,
    training protocols, and product reviews by subscribing to our
    newsletter. Receive exclusive insights straight to your inbox each week.

    Anavar Cycle Guide: Safe Dosage & Best Results
    2025

    This guide provides a comprehensive look at how to use Anavar safely while maximizing gains.
    From cycle length to dosage splits, we cover everything needed for
    optimal performance in 2025.

    What is Oxandrolone?

    Oxandrolone is a synthetic anabolic steroid derived from dihydrotestosterone (DHT).
    It’s known for its low androgenic activity and high anabolic potential, making it popular among bodybuilders
    and athletes seeking lean muscle gains with minimal side
    effects.

    What Is Anavar?

    Anavar is the brand name for Oxandrolone. Unlike many steroids,
    it has a gentle profile that supports strength and muscle retention while reducing
    fat. Its oral formulation offers convenience but requires careful liver
    support.

    Anavar Cycle for Men

    Typical male cycles run 4–6 weeks with doses ranging from
    20–40 mg per day. A common strategy is a split dose (10 mg twice
    daily) to maintain steady blood levels and minimize peaks that can stress the body.

    Anavar Only Cycle Results

    Users often report noticeable strength gains, improved muscle definition, and reduced body fat after a single
    Anavar cycle. Because it’s an oral steroid, results can appear within 2–3 weeks of consistent
    use.

    Anavar Fat Burning

    Anavar boosts basal metabolic rate and preserves lean tissue during calorie restriction. Combined with
    resistance training, users often see accelerated fat loss while maintaining
    muscle mass.

    Anavar Cycle Dosage Breakdown

    Beginners: 10 mg/day for 4 weeks

    Intermediate: 20–30 mg/day for 6 weeks

    Advanced: 30–40 mg/day for 8 weeks (often split into two
    doses)

    Adjustments should be made based on tolerance and desired outcomes.

    Anavar vs Winstrol

    Both are oral steroids, but Anavar is milder on joints and has a lower risk of acne.
    Winstrol offers higher androgenic effects, potentially leading to more pronounced
    muscle hardness but also increased side‑effects.

    How Long Does Anavar Stay in Your System?

    Detection windows vary by test type. Immunoassay screens typically detect Anavar metabolites up
    to 14 days post‑use; more sensitive LC-MS/MS
    methods can pick up residues for several weeks longer.

    Anavar and Test Cycle Dosage

    When stacking with testosterone, a common approach is 20–30 mg/day of Anavar alongside 200–400 mg/week of testosterone
    enanthate. This combination enhances muscle retention while supporting hormonal balance.

    Anavar Safe Dosage for Women

    Women should start low: 5–10 mg/day for 4 weeks. Due to its
    mild androgenic profile, the risk of virilization is lower than with other steroids, but caution remains essential.

    Anavar Dosage for Beginners

    Begin with 10 mg/day split into two doses (5 mg in morning, 5 mg in evening).

    Monitor how your body reacts before considering any increase.

    How Long for Anavar to Kick In?

    Users often notice initial strength gains within the first week.
    Visible changes in muscle definition typically emerge after 3–4 weeks
    of consistent use.

    Side Effects of Anavar in Men and Women

    Common side effects include acne, hair loss, mood swings,
    and mild liver strain. High doses or prolonged
    use can amplify these risks.

    Anavar Liver Toxicity

    Although Anavar is considered less hepatotoxic than other
    oral steroids, it still poses a risk to the liver, especially when taken at high doses or for extended periods.
    Regular liver function monitoring is advised.

    Side Effects in Men

    Men may experience decreased natural testosterone production,
    mild gynecomastia (rare), and potential cardiovascular strain if combined with other stimulants.

    Side Effects in Women

    Women face risks of virilization—deepening voice, hirsutism—and menstrual
    irregularities. Starting at the lowest effective dose mitigates these concerns.

    Drug Interactions with Anavar (Oxandrolone)

    Anavar can interact with medications that
    affect liver enzymes, such as certain antifungals and anticonvulsants.
    It may also amplify the effects of statins or other hepatotoxic
    drugs.

    Precautions When Using Anavar and What to Avoid

    Avoid stacking with other oral steroids without proper support.

    Refrain from exceeding recommended doses, and never use
    counterfeit products that may contain harmful contaminants.

    Anavar Before and After: What to Expect

    Before starting, expect a period of adjustment as your body acclimates.
    After the cycle, you should see improved muscle tone, strength retention,
    and possibly enhanced fat loss.

    Anavar vs Test: Which Is Better?

    Testosterone provides broad anabolic benefits but requires injections and can lead to water retention. Anavar offers lean gains with minimal water weight and is
    easier to administer orally.

    How Long Between Anavar Cycles?

    A minimum of 4–6 weeks off the steroid allows your body to recover
    and natural hormone levels to rebalance before
    considering another cycle.

    Anavar Post Cycle Therapy

    Because Anavar can suppress natural testosterone production, a short post-cycle therapy (PCT) using agents
    like Clomid or Nolvadex may be necessary for some users,
    especially those on higher doses.

    Best Stack with Anavar

    A popular stack includes:

    Anavar 20 mg/day

    Testosterone Enanthate 200 mg/week

    Trenbolone (if experienced) 300 mg/month

    This combination maximizes muscle retention while minimizing side effects.

    Anavar Cutting Cycle Example

    Weeks 1–4: 30 mg/day split, paired with a high‑protein diet and
    moderate cardio. Weeks 5–6: taper to 20 mg/day. Throughout, supplement with N-acetylcysteine for liver support.

    User Experiences and Testimonials

    Many users report significant strength gains and clearer muscle
    definition after a single Anavar cycle, citing minimal water retention and manageable side
    effects when dosed responsibly.

    Legal Status and Availability

    Anavar is classified as a controlled substance in many countries.
    It’s available by prescription only, and possession without a valid prescription can lead to legal
    consequences.

    Liver Support Supplements

    Common supplements include milk thistle, N-acetylcysteine, and SAMe.
    These help mitigate liver stress associated with oral steroid use.

    Nutrition and Training Tips During Anavar Cycle

    Consume 1–1.2 g protein per pound of body weight
    daily.

    Maintain a slight caloric deficit if cutting; a surplus for bulking.

    Focus on compound lifts (squats, deadlifts) to maximize anabolic stimulus.

    Common Myths and Misconceptions About Anavar

    “Myth: Anavar is safe for everyone.” Reality: Even low doses can affect
    liver function and hormone balance.

    “Myth: It’s free of side effects.” Reality: Acne, hair loss,
    and mood changes are common.

    Warnings About Counterfeit Products

    Counterfeit Anavar often contains toxic fillers or
    incorrect dosages. Purchase only from reputable pharmacies or licensed
    distributors to ensure safety.

    Frequently Asked Questions About Anavar

    How quickly does it work? Strength gains can start within a week; visible changes after
    3–4 weeks.

    Can I use it while pregnant? No—Anavar is contraindicated during pregnancy due to potential teratogenic effects.

    Is it safe for long‑term use? Prolonged use increases liver strain and hormonal suppression risks.

    Final Thoughts

    When used responsibly, Anavar offers a powerful tool
    for lean muscle gain, strength enhancement, and fat loss with a
    relatively mild side‑effect profile. Adhering to recommended dosages,
    monitoring health markers, and supporting the liver will help you
    achieve safe and effective results in 2025.

  6. dianabol and methyltestosterone cycle Metandienone
    An Overview

    1. What is C4 (C‑4) and why do people use it?

    C4 – also called C‑4, C‑4‑L, or simply “C” – is a synthetic
    anabolic–androgenic steroid (AAS).

    Its active ingredient is methenolone acetate (a derivative of
    methenolone), the same core compound that appears
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    Feature C4 (C‑4) Methandienone (Dianabol)

    Primary active compound Methenolone acetate Methandrostenolone

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    Half‑life ~12–18 h ~12 h

    Androgenic/estrogenic ratio High androgenic, moderate estrogenic Very high androgenic
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    1.2 Why C4 is Popular

    Oral administration – No injections required; easy to
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    Rapid onset – Significant increases in muscle
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    Strong anabolic effect – Promotes protein synthesis,
    nitrogen retention.

    Versatile use – Commonly used in bulking cycles or as “finishing” agents before competitions.

    2. How C4 Works on the Body

    2.1 Interaction with Androgen Receptors (AR)

    Binding: C4 diffuses into cells and binds to androgen receptors in skeletal muscle, liver,
    bone, and other tissues.

    Transcriptional activation: The ligand–receptor complex translocates to the
    nucleus, where it binds DNA at specific sites (androgen response elements) and activates transcription of target genes.

    2.2 Key Genes Upregulated

    Gene Function Effect on Muscle

    Myogenin Myogenic differentiation factor Promotes myoblast fusion into mature fibers

    MyoD Master regulator of myogenesis Drives muscle progenitor cells toward
    myogenic lineage

    IGF-1 (Acvr2b) Growth factor Enhances protein synthesis,
    satellite cell activation

    Myostatin (GDF8) Negative regulator of growth
    Downregulated → less inhibition on hypertrophy

    MSTN antagonist (e.g., follistatin) Inhibits myostatin signaling Promotes muscle mass increase

    These transcription factors and growth signals collectively shift the
    cellular environment toward a proliferative, anabolic state conducive to increased muscle fiber number.

    5. The Role of the Cytokine Network in Muscle
    Hypertrophy

    The cytokine network acts as a central integrator of systemic metabolic
    cues (e.g., insulin, IGF-1) and local tissue signals (e.g., myostatin).
    By modulating this network:

    IGF‑1/Insulin: Enhanced activation of the PI3K‑AKT pathway increases protein synthesis via mTORC1.

    IL‑6: Increases GLUT4 expression, improving glucose uptake and
    thereby providing more substrate for anabolic processes.

    TNF‑α & IL‑1β: At low levels may prime satellite cells for activation; chronic high levels can be catabolic.

    In skeletal muscle, the balance of these signals determines whether protein synthesis outweighs degradation. The cytokine milieu orchestrates this by influencing:

    Transcription Factors: NF‑κB (catabolism) vs FOXO (proteolysis), SMADs (TGF‑β signaling).

    Enzymes: E3 ubiquitin ligases like MuRF1 and Atrogin‑1 (atrophy genes) are upregulated by
    catabolic cytokines; downregulated when anabolic signals dominate.

    Proteasomal Activity: Enhanced by NF‑κB activation; inhibited by insulin/IGF‑1.

    In summary, the cytokine milieu shapes muscle protein synthesis through a complex network of signaling pathways.
    Pro‑inflammatory cytokines initiate and sustain catabolic processes
    via NF‑κB, STAT3, MAPK, PI3K/Akt, and JAK/STAT pathways, culminating in increased ubiquitination and
    proteasomal degradation. Conversely, anabolic cytokines (IL‑6, IL‑15) activate the PI3K/Akt/mTOR axis, promoting
    translational initiation and elongation, while anti‑inflammatory signals suppress catabolic pathways.
    The net effect on muscle protein synthesis depends on the
    balance between these opposing forces within the cytokine milieu.

    We need to rewrite this in 200-250 words (so about 210 words).
    It must be a summary of the original text but shortened to that word count, and it must not use the same wording as original.
    So we have to paraphrase, compress, and reduce length while covering main points:
    cytokine milieu influences muscle protein synthesis; pro-inflammatory cytokines inhibit via NF-κB/STAT3,
    activate ubiquitin-proteasome, autophagy etc.;
    anti-inflammatory cytokines promote via PI3K/Akt/mTOR,
    inhibit proteolysis; balance matters.

    Also need to mention specific pathways like mTORC1,
    FoxO, Atrogin-1, MuRF-1. Also mention that inflammatory environment can upregulate proteases and degrade muscle.

    Let’s produce a summary with about 300-350 words maybe?
    The original is long (~1200+ words). We can condense
    to ~250-300 words.

    We should avoid repeating too many times but keep key details.

    Also need to maintain referencing of specific molecules
    like IL-6, TNF-alpha, IFN-gamma. Also mention that chronic inflammation leads to muscle atrophy via proteolysis and autophagy.

    Ok let’s write.

    We will structure as: first paragraph summarizing general effect; second paragraph on inflammatory cytokines; third
    paragraph on signaling pathways and proteases; fourth paragraph on outcomes (atrophy, decreased protein synthesis).
    We’ll keep it concise but detailed. Let’s proceed.Impact of chronic inflammation on skeletal‑muscle homeostasis

    General outcome – Prolonged exposure to inflammatory mediators drives a shift from anabolic to catabolic processes
    in muscle fibers. Protein synthesis is suppressed, while proteolysis (via the ubiquitin–proteasome system and autophagy) increases, leading to net loss of myofibrillar proteins,
    reduced cross‑sectional area, impaired contractile function, and eventual atrophy.

    Key inflammatory signals – Tumor necrosis factor‑α (TNF‑α), interleukin‑6 (IL‑6), interferon‑γ (IFN‑γ)
    and reactive oxygen species are the principal cytokines/oxidants that mediate these effects by activating
    intracellular pathways in satellite cells, myoblasts, and mature fibers.

    Transduction pathways

    – NF‑κB activation: TNF‑α binds its receptor → IKK complex
    phosphorylates IκBα → degradation of IκBα releases NF‑κB (p65/p50)
    to translocate into the nucleus, where it induces expression of pro‑inflammatory genes and suppresses myogenic factors such as MyoD.

    – STAT1/STAT3 signaling: IFN‑γ or IL‑6 engagement leads to phosphorylation of STATs → dimerization and nuclear entry; STAT1 promotes apoptosis and inhibits differentiation, whereas activated STAT3 can have dual roles depending on the cellular context.

    – MAPK pathways (ERK, p38): These kinases modulate transcription factors that either support or inhibit
    myogenesis. For example, sustained ERK activation can drive proliferation but block terminal differentiation.

    Impact on Myogenic Differentiation

    The combined action of these signaling cascades reduces the expression of muscle-specific genes (e.g., MyoD, myogenin), inhibits fusion into multinucleated myotubes, and
    may even trigger cell death or senescence pathways.
    Consequently, stem cells exposed to an inflammatory milieu exhibit diminished
    regenerative potential.

    4. Implications for Stem‑Cell‑Based Muscle Therapies

    Selection of Cell Source

    – Autologous vs Allogeneic: Autologous MSCs may still be affected by the
    patient’s systemic inflammation, whereas allogeneic cells from healthy donors could offer a more robust therapeutic response.

    – Pre‑conditioning Strategies: Exposing stem cells to anti‑inflammatory cytokines (e.g., IL‑10) or hypoxic pre‑culture can enhance
    their resilience.

    Timing of Transplantation

    – Early intervention, before chronic inflammation establishes
    extensive fibrosis, may improve engraftment and functional outcomes.

    – Post‑operative monitoring for elevated pro‑inflammatory
    markers could inform optimal windows for cell delivery.

    Adjunct Therapies

    – Combining stem cell therapy with pharmacologic agents that suppress systemic inflammation (e.g., statins, ACE
    inhibitors) may synergistically promote tissue repair.
    – Targeted delivery of immunomodulatory molecules at the surgical site can localize anti‑inflammatory effects without compromising
    overall immune competence.

    Monitoring and Biomarkers

    – Serial assessment of circulating cytokines, CRP levels, and leukocyte profiles could serve as early indicators
    of successful integration or complications.
    – Imaging modalities (MRI, PET) coupled with molecular tracers for inflammation may
    provide non‑invasive evaluation of the reparative process.

    Conclusion

    The systemic inflammatory milieu profoundly influences the trajectory of tissue regeneration following
    surgical interventions. By comprehensively understanding the cellular
    and molecular interplay between innate immunity and regenerative pathways, we can devise targeted strategies—ranging from pharmacologic modulation to biomaterial engineering—that harmonize
    inflammation with healing. Such integrative approaches hold promise for
    enhancing functional recovery in a variety of clinical settings, ultimately translating into improved patient outcomes.

    References

    (The review would include a detailed bibliography of primary research articles and seminal reviews relevant to the
    topics discussed.)

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    Anavar (Oxandrolone)

    Feature Details

    Drug class Anabolic–androgenic steroid (AAS) – a synthetic derivative of testosterone.

    Common brand name Anavar® (often sold in 10 mg or 20 mg tablets).

    Typical prescription strength 5–10 mg daily for men, 2.5–5 mg daily for
    women (dose varies by medical indication).

    Medical Uses

    Weight‑gain therapy

    For patients who cannot maintain weight due
    to chronic illness or injury (e.g., AIDS, burns, trauma).

    Anemia support

    Stimulates erythropoiesis (red‑blood‑cell production) when iron deficiency or
    anemia is present.

    Bone loss prevention

    Occasionally used off‑label for osteoporosis in postmenopausal women to help maintain bone density.

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    Rarely prescribed as part of a hormone‑suppression protocol.

    How It Works

    Anabolic effect: Enhances protein synthesis,
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    Red‑blood‑cell production: Increases erythropoietin release → stimulates
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    Fatigue relief: Higher hemoglobin improves oxygen delivery to tissues, reducing fatigue.

    Typical Dosage & Administration

    Age Weight (approx.) Dose Frequency

    2–4 years 12–14 kg 0.5 mg/kg/day Once daily

    5–7 years 15–20 kg 0.5 mg/kg/day Once daily

    Notes:

    Start at the lower end; adjust based on response and side effects.

    Use a calibrated oral syringe or dropper for accurate dosing.

    Monitoring & Follow‑Up

    Parameter Frequency Action

    Hemoglobin (Hb) Every 3–4 weeks initially, then every 6–8 weeks once stable If Hb  13 g/dL, consider
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    Serum ferritin Every 3 months after stabilization Target range 100–200 ng/mL; if
    > 200 ng/mL, reassess iron status and dietary intake

    Growth parameters (height, weight) Monthly Adjust overall
    nutritional plan as needed

    Adverse events (nausea, vomiting, constipation) At each visit Manage with supportive measures or dose adjustment

    Special Considerations:

    Concurrent Iron Therapy: If the child is on oral iron supplements, adjust doses to avoid excessive iron overload.

    Other Medical Conditions: Review any comorbidities that may
    affect growth (e.g., endocrine disorders) and coordinate
    care accordingly.

    6. Summary

    Baseline: Comprehensive assessment of current intake, body composition, metabolic
    rate, hormonal profile, physical activity, and dietary habits is essential.

    Intervention:

    – Increase overall energy by ~500 kcal/day with nutrient‑dense foods.

    – Target macronutrient shifts (protein ↑, carbs ↓) while
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    – Monitor changes in body composition (lean mass vs fat) via DXA/air displacement plethysmography.

    Monitoring:

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