ソフトバンクモバイルとイー・アクセス（イー・モバイル）が合併

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1. Eugenesom より:

   2025年8月20日 7:59 PM

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2. How CrossFit Can Improve Athletic Performance より:

   2025年11月1日 7:38 AM

   It was not until the 1950’s, nonetheless, that athletes started to discover that
   AAS might tremendously enhance their muscularity. Still, throughout the 1960’s and even into the 1970’s, AAS use was confined largely to
   the elite ranges of sport. The efficacy of AAS remained a well-kept secret amongst athletes; sports physicians and medical
   texts had been still extensively proclaiming that AAS have been ineffective
   for gaining muscle (Casner et al., 1971; Haupt and Rovere,
   1984; Wade, 1972). The problem of anabolic-androgenic steroid (AAS) abuse has just
   lately generated widespread public and media attention.
   Though a quantity of constructive results of AAS use had been described, supraphysiological doses and AASs abuse and misuse might result
   in critical consequences in all physique tissues and organs (Figure 2).
   Medication often known as “anabolic steroids” are made in laboratories and have the same chemical structure because the steroids
   discovered within the male intercourse hormone testosterone.
   The muscle-building (anabolic) and masculinizing (androgenic) results of these medication make
   them interesting to athletes and bodybuilders.
   If a girl requires therapy while making an attempt to get pregnant, there are effective alternate
   options to steroids that a physician might contemplate.
   In terms of steroids and breastfeeding or lactation, it isn’t yet identified
   if anabolics cross into breast milk. A medical physician can present correct details about steroids
   and breastfeeding and steroids and being pregnant.

   Steroid dependancy is a harmful and complicated concern that
   goes far beyond the pursuit of muscle positive aspects or enhanced performance.
   What may start as a desire to realize physical perfection shortly spirals
   right into a dependence on the drug, each bodily and mentally.
   The body’s natural hormone manufacturing is disrupted,
   inflicting long-term well being points, whereas the psychological need to take care
   of strength and look drives customers deeper into addiction.
   Recognizing the signs of steroid abuse early on is crucial for preventing irreversible damage to the physique and thoughts.

   ND didn’t restore mRNA expression of MHC isoforms in response to hindlimb unloading in adult mice (3).
   Studies consisted of sixty four experimental teams handled with AAS and forty four non-AAS
   experimental and management groups. The most commonly administered AAS had been nandrolone decanoate (ND) (3,
   eleven, 19, 21, 22, 25, 30, 31, 33, 36, 38, 39, 43), testosterone esters (TE) (5, 6, 9, 10, 14, 15,
   20, 35, 39), and dihydrotestosterone (DHT; 6–9, 18, 41).

   Extreme levels of testosterone sign the physique
   that it doesn’t need to produce pure quantities of
   the hormone anymore, which leads to testicular atrophy.

   Consequently, anabolics can render a person infertile throughout a interval of abuse.
   This aspect impact is understood to improve spontaneously
   after the person quits utilizing the medicine.

   Accredited training actions, evidence-based scientific resources and greatest follow guidelines.
   If you’re misusing or abusing steroids and need to cease, be sincere with your physician to get the
   best assist. Folks can become dependent on steroids, especially when they’re relied on for confidence and self-esteem.
   Males are targeted with commercials and articles about testosterone’s benefits and the means to enhance their ranges.

   Understanding these pink flags is essential for friends, family
   members, and users. For males, long-term use can lead to erectile
   dysfunction, reduced libido, and, in extreme
   circumstances, impotence. For ladies, steroid abuse could trigger clitoral enlargement,
   deepening of the voice, and hair loss—effects that will turn into everlasting, even after stopping the drug.

   Athletic organizations, including skilled sports activities leagues and the Olympics, have
   strict rules against using anabolic steroids.

   Athletes caught using steroids How CrossFit Can Improve Athletic Performance face suspensions, fines, and bans from competitors.

   In the legal system, being caught with or distributing anabolic steroids with no prescription may find yourself
   in fines, jail time, and a everlasting criminal record.
   Steroids could cause irreversible damage to your body and mind, from
   life-threatening conditions like liver and kidney failure to psychological adjustments that impression temper and habits.

   AAS exert a variety of physiological results that end result in the activation of central signaling, leading to opposed results.

   Moreover, extreme use of AAS which may be categorized as AAS abuse; is linked to biological and psychological pathologies, which might result in mortality.
   Issues arising from steroid abuse contain both mobile and physiological problems.
   Cellular complications come up when activation of signaling proteins like mTOR, Akt, and so forth.
   leads to alteration in protein synthesis pathways, cell cycle, oxidative stress, and apoptosis,
   contributing to wreck on the mobile stage. Medical problems budding from these altered physiological processes lead
   to clinical results like testicular dysfunction, acne, gynecomastia, and neuropsychiatric disorders.

   Regardless Of potential therapeutic advantages, AAS use is prohibited by the World Anti-Doping Company (WADA) due
   to concerns over adverse well being effects.

   Some individuals experiencing steroid withdrawal receive medication to help restore their hormonal techniques.
   Others are treated with behavioral therapies for withdrawal signs
   that transcend pharmacological remedy. Dr. O’Connor has over 20
   years of experience treating men and women with a historical
   past of anabolic steroid, SARM, and PED use.
   Consequently, an argument might be made to perceive these AAS-induced cardiac adjustments
   as risk modifiers when estimating CVD danger utilizing algorithms similar to SCORE2 or PCE, and will help in ‘grey zone’
   danger estimation situations. To manage this side effect, some AAS
   customers resort to ancillary medicine for therapy.
   This consists of use of the oral prescription drug isotretinoin by a small percentage of
   users (65, 67). Isotretinoin is taken into account to be the best medication in opposition to
   acne (68). Despite its effectiveness, isotretinoin treatment is
   generally reserved for extreme nodulocystic scarring acne
   or pimples proof against different therapies (68).